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Mephisto was the first Prime Evil to be captured, and his Soulstone was put into the hands of the local priesthood, the Zakarum, for safekeeping. They kept it under a Zakarum temple in what would eventually become Kurast. In the meantime, the Horadrim pursued and eventually captured all three of the Prime Evils.
Eventually, however, Mephisto managed to overcome the powers of the Soulstone that imprisoned him enough to influence and corrupt the Zakarum. The demon then had the priests work spells to shatter the Soulstone into seven shards, breaking the mystic seal and freeing the Lord of Hatred.
